London, Dec 1 : In a new study, researchers at University of California Los Angeles (UCLA) have for the first time demonstrated how microscopic crystals form sound and gravity sensors inside the inner ear.
They found that the crystals, located at the ends of cilia (tiny cellular hairs in the ear that move and transmit signals) play an important role in detecting sound, maintaining balance and regulating movement.
In fact, it is the dislodged ear crystals that are responsible for the most common form of vertigo, called benign paroxysmal positional vertigo, which plagues up to 10 percent of people older than 60 and causes 20 percent of patients' dizziness complaints.
The results of the new study may offer a potential gene target for the treatment of people suffering from common hearing, vertigo and balance problems related to cilia disorders.
"People have known for a long time about the importance of cilia for propelling sperm up the uterus and moving mucus out of the lungs," Nature quoted Kent Hill, associate professor of microbiology, immunology and molecular genetics at UCLA's David Geffen School of Medicine and College of Letters and Science.
He added: "Our study illustrates that cilia perform many additional jobs that are essential to how our bodies develop and work."
For the study, the researchers used high-speed, high-definition video imaging to watch cilia moving in real time inside the developing ears of embryonic zebrafish, which are small bony fish that undergo stages of development similar to humans and other vertebrates, making them useful models for research.
Cilia in the fish were labelled with fluorescent probes and then video microscopy was used to visualize the cilia and other inner ear structures.
The researchers observed that in the control fish, long cilia beat like tiny oars, causing tiny particles to circle in a vortex around them. The tornado of whirling particles accumulated at the proper location to form the inner ear's crystalline sensors.
"We next blocked expression of a gene that controls dynein -- a tiny molecular motor that drives cilia movement. When we examined the embryos, we saw that cilia movement came to a halt. As a result, the particles did not assemble in the correct site. So not only did ear crystals form in the wrong place, but they were misshapen and abnormally sized," said Hill.
He added: "While it's been suggested that cilia movement contributes to the formation of ear crystals, this idea had never been tested before," he added. "Our findings show that cilia in the ear do move and demonstrate that cilia movement is needed for ear crystals to assemble in the right place."
He then said that the findings offer promise for the treatment of patients with hearing disorders and people with ciliopathies, disorders marked by poor cilia function.
The above conditions include sperm-related infertility, polycystic kidney disease, lung and respiratory disorders, swelling of the brain and reversal of the internal organs' sites from one side of the body to the other.
"The idea that physical movement can influence vertebrate development is very provocative. Scientists typically look at whether a particular gene is switched on or off, or if a particular protein is activated that determines if a tissue develops normally. In this case, microscopic currents in the fluid surrounding developing tissue are affecting its development. We need to understand more details of this process and determine how common it is during development," said Hill.
The study was published in the latest advance online edition of Nature.
--- ANI
Most
Visited Pages: