The research team at the RIKEN Brain Science Institute has found that an enzyme called Rines regulates MAO-A, a major brain protein controlling emotion and mood. The enzyme is a potentially promising drug target for treating diseases associated with emotions such as depression.
Monoamine oxidase A (MAO-A) is an enzyme that breaks down serotonin, norephinephrine and dopamine, neurotransmitters well-known for their influence on emotion and mood.
Nicknamed the "warrior gene", a variant of the MAOA gene has been associated with increased risk of violent and anti-social behavior.
While evidence points to a link between MAO-A levels and various emotional patterns, however, the mechanism controlling MAO-A levels in the brain has remained unknown.
The research team headed by Jun Aruga has shown for the first time that a ligase named Rines (RING finger-type E3 ubiquitin ligase) regulates these levels.
Their research shows that mice without the Rines gene exhibit impaired stress responses and enhanced anxiety, controlled in part through the regulation of MAO-A levels.
The study is published in Journal of Neuroscience.
--ANI (Posted on 07-08-2013)