health-news

Why people tend to put on weight

Washington, Jan. 8 : A new study has revealed that a protein in the brain helps regulate food intake and body weight.


The findings reveal a potential new avenue for the treatment of obesity and may help explain why medications that are prescribed for epilepsy and other conditions that interfere with this protein, such as gabapentin and pregabalin, can cause weight gain.

The protein a€" alpha2/delta-1 a€" has not been linked previously to obesity.
A team led by Maribel Rios, Ph.D., associate professor in the department of neuroscience at Tufts University School of Medicine, found that alpha2/delta-1 facilitates the function of another protein called brain-derived neurotrophic factor (BDNF).

Rios, also a member of the cellular and molecular physiology and neuroscience program faculties at the Sackler School of Graduate Biomedical Sciences at Tufts, said that they know that low levels of the BDNF protein in the brain lead to overeating and dramatic obesity in mice. Deficiencies in BDNF have also been linked to obesity in humans.

He said that now, they have discovered that the alpha2/delta-1 protein is necessary for normal BDNF function, giving us a potential new target for novel obesity treatments.

Rios and colleagues discovered that low levels of BDNF were associated with decreased function of alpha2/delta-1 in the hypothalamus, a brain region that is critical to the regulation of food intake and weight.

When the team inhibited the alpha2/delta-1 protein in normal mice, mice ate significantly more food and gained weight. Conversely, when the team corrected the alpha 2/delta-1 deficiency in mice with reduced BDNF levels, overeating and weight gain were mitigated. In addition, blood sugar levels (related to diabetes in humans) were normalized.

The study has been published in the Journal of Neuroscience.

--ANI (Posted on 08-01-2014)

health-news headlines

Four must eat white vegetables

Obesity can aggravate bone and muscle loss

'Severely infectious' bacterial strain can survive in contact lens solution

People undergoing weight loss surgery experience changes in appetite, taste and smell

Masculine boys and feminine girls likelier to engage in behaviors that poses cancer risk

Embrace daily massage to improve health

Internet use to ward off depression among elderly

BMI linked to postmenopausal breast cancer regardless of body shape

Protein crucial for sperm-egg fertilization discovered

Now, drug that combats measles and prevents virus from spreading

How memories stick together

Leeches can fix torn ear!

Quick Links: Goa | Munnar | Pondicherry | Free Yearly Horoscope '2014

Comments

Your e-mail:


Your Full Name:


Type verification image:
verification image, type it in the box

Message:

Back to Top