Getting fatter with age? Blame it on brown fat

Tokyo, Jan 3 : In your 40s and not been able to cut that extra flab? It could be the end of 'good' brown fat in the back of your neck.

As we age, thermogenic activity of brown fat - good fat that helps burn bad white fat around our bellies - slows down, claimed a new study.

To beat this, those on the other side of the 40s would have to clock extra hours on the treadmill and eat more salads than their younger counterparts in order to shed weight, said the research published in The FASEB Journal.

"Our brown fat stops working as we age. Unfortunately, until a way to turn it back on is developed, we would have to be prepared to eat more salads and lean proteins, while logging more miles on the treadmill than our younger counterparts," said Gerald Weissmann, editor-in-chief of The FASEB Journal that published the study.

To make this happen, scientists analysed two groups of mice. They knocked out the platelet-activating factor receptors (PAFR) gene in first group. The second group was normal.

PAFR-deficient mice developed a more severe obese state characterised by higher body and epididymal fat mass with age than that of the normal group.

"The research revealed that PAFR-deficiency causes brown adipose tissue (BAT) dysfunction - which converges to induce the development of obesity - due to impaired thermogenic activity of BAT," said Junko Sugatani, a researcher at school of pharmaceutical sciences at University of Shizuoka in Shizuoka, Japan.

Additionally, the researchers also discovered a possible metabolic on/off switch that could reactivate brown fat, said the study.

This breakthrough could elucidate the molecular mechanism underlying the PAF/PAF receptor-mediated anti-obesity, leading to the development of new targets for the treatment of obesity and related disorders, such as diabetes, high blood pressure, heart disease, cancer, infertility and ulcers, concluded the study.

--IANS (Posted on 03-01-2014)

health-news headlines

Lost stem cells are replaced by non-stem cells: Study

Brown fat breakthrough may be 'holy grail' of weight loss

Tuberculosis drug could also help treat other diseases

New method to fight Malaria drug resistance discovered

Dengue fever could soon be history

Four must eat white vegetables

Obesity can aggravate bone and muscle loss

'Severely infectious' bacterial strain can survive in contact lens solution

People undergoing weight loss surgery experience changes in appetite, taste and smell

Masculine boys and feminine girls likelier to engage in behaviors that poses cancer risk

Embrace daily massage to improve health

Internet use to ward off depression among elderly

Quick Links: Goa | Munnar | Pondicherry | Free Yearly Horoscope '2014


Your e-mail:

Your Full Name:

Type verification image:
verification image, type it in the box


Back to Top