health-news

Key protein may eradicate rare soft-tissue cancer

New York, Dec 30 : A rare soft-tissue cancer may be eradicated simply by inhibiting a key protein involved in its growth, research suggests.


Scientists have found that inhibiting the action of a protein called BRD4 caused cancer cells to die in a mouse model of malignant peripheral nerve sheath tumours (MPNSTs).

"This study not only identifies a potential new therapeutic target to combat MPNST, an incurable type of cancer that is typically fatal but also provides important insight into what causes these tumours to develop," said Lu Le, assistant professor of dermatology at UT Southwestern Medical Centre and senior author of the study.

Researchers determined that BRD4, a bromodomain protein that binds to DNA to regulate gene activation, is expressed at an unusually high level in MPNST cancer cells.

When researchers inhibited BRD4 either genetically in the mice or pharmacologically by administering a compound called JQ1, the tumours began to shrink.

"These treatments suppressed tumour growth and caused the cancer cells to undergo cell death. This is why BRD4 inhibition is exquisitely effective against MPNSTs and may represent a paradigm shift in therapy for these patients," said the study published in the journal Cell Reports.

MPNSTs are highly aggressive sarcomas that form around nerves. These tumours can develop sporadically, but about half of cases are in patients with a genetic disorder called neurofibromatosis type 1 (NF1) that affects 1 in 3,500 people.

The five-year survival rate for MPNST patients is about 50 percent.

UT Southwestern is now working with a pharmaceutical company to develop a similar BRD4-inhibiting drug to launch a clinical trial for MPNST patients.

--IANS (Posted on 30-12-2013)

health-news headlines

How food texture affects our calorie intake

Cheap 'magic' polypill helps fight heart diseases

Extroverts make for happier humans across cultures

Low-calorie restaurant menus may be making us unhealthier

Why rice is good for your health

Pregnant women with high BP risk preterm delivery and low birth weight

Casual marijuana use could lead to brain abnormalities in young adults

Antibiotics improve growth in kids in developing countries

Anti-depressants during pregnancy linked to autism and developmental delays in boys

Girls' mental health suffers when romances play out differently than they imagined

Now, faster, cheaper blood test to accurately diagnose asthma

Genetic therapy may repair spinal chord: Study

Quick Links: Goa | Munnar | Pondicherry | Free Yearly Horoscope '2014

Comments

Your e-mail:


Your Full Name:


Type verification image:
verification image, type it in the box

Message:

Back to Top