How removing sperm and egg producing cells extends lifespan
Removal of germ cells - the sperm and egg producing cells - increases longevity of the roundworm Caenorhabditis elegans, but the underlying molecular mechanisms were a mystery.
Now scientists at the Cologne-based Max Planck Institute for Biology of Ageing, have discovered that germ cell removal flips a "molecular switch" that extends the life span by using components of a "developmental clock".
The roundworm Caenorhabditis elegans is a commonly used model organism in the field of ageing research. It develops from an egg to adult through four larval stages. These developmental stages are controlled by a developmental clock.
Yidong Shen and colleagues working in the department of Director Adam Antebi used a laser to remove the germ cells.
They found that the remaining gonadal cells trigger production of a steroid hormone called dafachronic acid. Dafachronic acid activates so-called microRNAs, which work as tiny molecular switches causing changes in gene expression that promote longevity.
Interestingly, this same steroid hormone-microRNA switch was previously shown by Antebi and colleagues to be part of the developmental clock.
Thus, the loss of the germ cells ultimately causes the worm to use developmental timers to put in motion a life-prolonging programme.