Soon, vaccine that stops malaria parasites from multiplying
Scientists have identified a substance, or antigen, that generates antibodies that can hinder the ability of malaria parasites to multiply, which may protect against severe malaria infection.
The antigen, which is known as PfSEA-1, was linked to reduced parasite levels among children and adults in malaria-endemic areas and it was found that mice exposed to PfSEA-1 in an investigational vaccine also experienced lower malaria parasite levels.
Multiple tests confirmed that antibodies to PfSEA-1 halted malaria infection at the point when the parasite leaves one red blood cell to invade a new one.
This stage offers a unique target for future malaria vaccines as previous vaccine candidates have tried to block the stage when parasites enter red blood cells.
The study was published in Science.
(Posted on 23-05-2014)