Australian researchers identify genes behind obsessive-compulsive disorder

IANS May 13, 2025 406 views

Australian researchers have made a major breakthrough in understanding OCD by identifying 250 genes linked to the disorder. The study analyzed DNA from over 50,000 people with OCD, revealing genetic connections to brain regions already associated with the condition. These findings could lead to faster diagnosis and more effective treatments, including repurposing existing medications. The research also highlights genetic overlaps with anxiety, depression, and eating disorders, underscoring OCD’s complexity.

"We’ve been working on this for many years, but these findings have dramatically increased our knowledge of the genetic basis of OCD." – Eske Derks
Australian researchers identify genes behind obsessive-compulsive disorder
Sydney, May 13: Australian researchers have identified genes linked to obsessive-compulsive disorder (OCD), offering new hope for improved diagnosis and treatment of the debilitating mental health condition.

Key Points

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Study analyzed DNA from 50,000 OCD patients

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Genes active in hippocampus and cerebral cortex

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Genetic overlap with anxiety and depression

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Findings could lead to repurposed treatments

OCD is a mental condition and features a pattern of unwanted thoughts and fears known as obsessions.

Researchers at QIMR Berghofer, formerly the Queensland Institute of Medical Research, found 30 regions of the human genome and around 250 genes associated with the disorder, Xinhua news agency reported.

The team identified the genes by analysing DNA from more than 50,000 people with OCD and 2 million without the condition.

"We've been working on this for many years, but these findings have dramatically increased our knowledge of the genetic basis of OCD," said Eske Derks, lead researcher and head of the Translational Neurogenomics Laboratory at QIMR Berghofer.

The genes identified are most active in the hippocampus, striatum, and cerebral cortex, areas of the brain already linked to OCD in previous neurological studies, according to the research, published in the journal Nature Genetics.

The findings also showed significant genetic overlap with other mental conditions such as anxiety, depression, anorexia, and other eating disorders. The study further highlights OCD's complexity.

OCD affects approximately 1 per cent to 3 per cent of the global population, ranging from compulsive cleaning and checking to fears about causing harm, inappropriate thoughts, or obsessive doubts about relationships and responsibilities.

"It not only impacts the individual but also the family, because everyone is trying to accommodate the OCD," said clinical psychologist Emily O'Leary.

She added that people with OCD are often trapped in constant fear of doing something wrong or harming those they love.

The study could fast-track diagnosis and lead to more targeted treatment, such as exploring how existing drugs used for other conditions could help treat OCD, said the researchers.

Reader Comments

Here are 6 diverse Indian perspective comments for the article:
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Priya K.
This is groundbreaking research! In India, mental health is still stigmatized and OCD is often dismissed as just being "too particular". Hope these findings lead to better awareness and treatment options here. 🙏
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Rahul S.
Interesting study but I wonder how applicable these findings are to Indian population. Our genetic makeup and environmental factors are quite different from Western countries. Would like to see similar research done in India.
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Ananya M.
As someone with OCD, this gives me hope! In India, people often tell me to "just stop thinking about it" or suggest religious solutions. Finally some scientific understanding of what we go through. 💜
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Vikram J.
Good research but treatment accessibility is the real challenge. Even in metro cities, finding proper OCD specialists is difficult. What about rural areas? Hope this leads to more trained professionals in India.
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Sunita P.
The genetic overlap with other disorders is fascinating! Maybe this explains why so many people in my family have different but related mental health conditions. We need more open discussions about this in Indian families.
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Arjun T.
While the science is impressive, we must remember that genes aren't destiny. Lifestyle, therapy and social support matter too. In Indian context, family support can make huge difference in managing OCD.

We welcome thoughtful discussions from our readers. Please keep comments respectful and on-topic.

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Tags:
OCD research QIMR Berghofer genetic study mental health Eske Derks anxiety disorders