health-news

New research may help fight motor neurone disease

Washington, Sept. 29 : Researchers have investigated why the progression of motor neurone disease following onset of symptoms varies in speed, even in the presence of a known genetic cause of the condition.


MND is an incurable disease destroying the body's cells which control movement causing progressive disability. Present treatment options for those with MND only have a modest effect in improving the patient's quality of life.

Professor Pamela Shaw, Director of SITraN, and her research team worked in collaboration with a fellow world leading MND scientist Dr Caterina Bendotti and her group at the Mario Negri Institute for Pharmacological Research in Milan, Italy investigated two mouse models of MND caused by an alteration in the SOD1 gene, a known cause of MND in humans. One of the strains had a rapidly progressing disease course and the other a much slower change in the symptoms of MND.

The teams from Sheffield and Milan looked at the factors which might explain the differences observed in speed and severity in the progression of the disease.

They used a scientific technique known as gene expression profiling to identify factors within motor neurones that control vulnerability or resistance to MND in order to shed light on the factors important for the speed of motor neurone injury in human patients.

The study revealed new evidence, at the point of onset of the disease, before muscle weakness was observed, showing key differences in major molecular pathways and the way the protective systems of the body responded, between the profiles of the rapid progressing and slow progressing mouse models.

The research has been published in the scientific journal Brain.

--ANI (Posted on 29-09-2013)

health-news headlines

Summer diet: Hog on fruits, veggies to stay active

Timeless beauty tips to follow

Cellulite facts worth knowing

Want to de-stress? Sex can help you

People are more concerned about their health at start of the week than weekends

Brain's anti-distraction system found

Chronic inflammation associated with aggressive prostate cancer

Easter chocolate can be good for health

'Smart' device that engineers cells to kill cancer

Lost stem cells are replaced by non-stem cells: Study

Brown fat breakthrough may be 'holy grail' of weight loss

Tuberculosis drug could also help treat other diseases

Quick Links: Goa | Munnar | Pondicherry | Free Yearly Horoscope '2014

Comments

Your e-mail:


Your Full Name:


Type verification image:
verification image, type it in the box

Message:

Back to Top