health-news

Vitamin D-based treatment key to halting MS

Washington, Sept. 28 : Researchers have discovered a vitamin D-based treatment that can halt - and even reverse - the course of the disease in a mouse model of Multiple Sclerosis (MS).


The treatment involves giving mice that exhibit MS symptoms a single dose of calcitriol, the active hormone form of vitamin D, followed by ongoing vitamin D supplements through the diet.

Lead scientist biochemistry professor Colleen Hayes said that all of the animals just got better and better, and the longer we watched them, the more neurological function they regained.

While scientists don't fully understand what triggers MS, some studies have linked low levels of vitamin D with a higher risk of developing the disease. Hayes has been studying this "vitamin D hypothesis" for the past 25 years with the long-term goal of uncovering novel preventive measures and treatments.

Over the years, she and her researchers have revealed some of the molecular mechanisms involved in vitamin D's protective actions, and also explained how vitamin D interactions with estrogen may influence MS disease risk and progression in women.

First, Hayes' team compared the effectiveness of a single dose of calcitriol to that of a comparable dose of a glucocorticoid, a drug now administered to MS patients who experience a bad neurological episode. Calcitriol came out ahead, inducing a nine-day remission in 92 percent of mice on average, versus a six-day remission in 58 percent for mice that received glucocorticoid.

Next, Hayes' team tried a weekly dose of calcitriol. They found that a weekly dose reversed the disease and sustained remission indefinitely.

But calcitriol can carry some strong side effects - it's a "biological sledgehammer" that can raise blood calcium levels in people, Hayes says - so she tried a third regimen: a single dose of calcitriol, followed by ongoing vitamin D supplements in the diet.

The study has been published online in the Journal of Neuroimmunology.

--ANI (Posted on 28-09-2013)

health-news headlines

Colon cancer linked to dietary fats

Now, smart pill bottle that help you take your meds on time

Ginseng can help treat and prevent influenza and respiratory virus

Now, 3D-printed plaster cast to heal wound faster

How bariatric surgery can help control diabetes

McDonaldisation of gym culture spreading fast: Study

New drug to treat depression?

Now, the ICU comes home - at a fraction of the cost (Health Feature)

Malnutrition not priority for most parties: CRY

Testosterone levels in womb may impact your health

Bone marrow can cure blood disorders

Heart's development doesn't stop with birth

Quick Links: Goa | Munnar | Pondicherry | Free Yearly Horoscope '2014

Comments

Your e-mail:


Your Full Name:


Type verification image:
verification image, type it in the box

Message:

Back to Top