New procedure makes limb transplant easier

New York, Jan 10 : A new procedure for limb transplant has opened a fresh window for patients suffering from facial injuries or hand/arm amputation.

The key lies in inducing immune tolerance - essentially tricking a recipient's immune system into accepting donor tissue - could be an ideal solution to free patients from lifelong immuno-suppression, said researchers at Massachusetts General Hospital (MGH) in the US.

Patients who undergo limb transplants need suppression of the immune response - via drugs or radiation - in order to prevent the rejection of grafts or transplants.

"The need for lifelong immuno-suppression to prevent graft rejection is the most important challenge. Most potential recipients of what are called vascularised composite allografts (VCAs) are young and would face increased risks of infection, even some types of cancer, over many years," said Curtis L. Cetrulo, head of plastic and reconstructive surgery at MGH and senior author.

VCAs involve transplantation of muscle, bone, skin and nerves to replace amputated hands and arms and to repair severe facial injuries, said the study published in the American Journal of Transplantation.

"Bringing immune tolerance to hand and face transplantation would result in a paradigm shift in the way we treat those injuries. Tolerance would give us a unique tool - a real game changer - with which to help these patients," Cetrulo added.

In several previous attempts to induce VCA tolerance, bone and muscle tissue were accepted but the skin was rejected and eventually separated from the underlying tissue.

"If all goes well, the procedure might be ready for testing in a clinical trial in a year," added Cetrulo.

--IANS (Posted on 10-01-2014)

health-news headlines

Lost stem cells are replaced by non-stem cells: Study

Brown fat breakthrough may be 'holy grail' of weight loss

Tuberculosis drug could also help treat other diseases

New method to fight Malaria drug resistance discovered

Dengue fever could soon be history

Four must eat white vegetables

Obesity can aggravate bone and muscle loss

'Severely infectious' bacterial strain can survive in contact lens solution

People undergoing weight loss surgery experience changes in appetite, taste and smell

Masculine boys and feminine girls likelier to engage in behaviors that poses cancer risk

Embrace daily massage to improve health

Internet use to ward off depression among elderly

Quick Links: Goa | Munnar | Pondicherry | Free Yearly Horoscope '2014


Your e-mail:

Your Full Name:

Type verification image:
verification image, type it in the box


Back to Top