Poor sleep can lead to schizophrenia symptoms
Irregular sleep patterns and desynchronised brain activity during sleep could trigger some of the symptoms of schizophrenia.
The findings suggest that these prolonged disturbances might be a cause and not just a consequence of the disorder's debilitating effects.
The possible link between poor sleep and schizophrenia prompted the research team, led by scientists from the University of Bristol, the Lilly Centre for Cognitive Neuroscience and funded by the Medical Research Council (MRC), to explore the impact of irregular sleep patterns on the brain by recording electrical brain activity in multiple brain regions during sleep.
For many people, sleep deprivation can affect mood, concentration and stress levels. In extreme cases, prolonged sleep deprivation can induce hallucinations, memory loss and confusion all of which are also symptoms associated with schizophrenia.
"Sleep disturbances are well-documented in the disease, though often regarded as side effects and poorly understood in terms of their potential to actually trigger its symptoms," said Dr Ullrich Bartsch, one of the study's researchers.
Using a rat model of the disease, the team's recordings showed desynchronisation of the waves of activity, which normally travel from the front to the back of the brain during deep sleep. In particular the information flow between the hippocampus - involved in memory formation, and the frontal cortex - involved in decision-making, appeared to be disrupted.
The team's findings reported distinct irregular sleep patterns very similar to those observed in schizophrenia patients.
The findings from this study provide new angles for neurocognitive therapy in schizophrenia and related psychiatric diseases.
The findings were published in the journal Neuron.