Caffeine-gold combo may help in fight against cancer
A new study has shown that combining a caffeine-based compound with a small amount of gold could someday be used as a tool in the fight against cancer.
Angela Casini, Michel Picquet and colleagues note that caffeine and certain caffeine-based compounds have recently been in the spotlight as possible anticancer treatments.
But drinking gallons of coffee, sodas and energy drinks isn't the solution. And the regular caffeine in these drinks would start to have negative effects on healthy cells, too, at the levels necessary to kill cancerous ones.
So, the research team put the two together into certain configurations to see whether the new caffeine-based gold compounds could selectively stop cancer cells from growing without hurting other cells.
They made a series of seven new compounds, called caffeine-based gold (I) N-heterocyclic carbenes, in the laboratory and studied them.
The scientists found that, at certain concentrations, one of the compounds of the series selectively killed human ovarian cancer cells without harming healthy cells.
In addition, the compound targeted a type of DNA architecture, called "G-quadruplex," that is associated with cancer.
The study was published in the ACS journal Inorganic Chemistry.
(Posted on 27-02-2014)
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