"I was unbelievably naive and I didn't really understand how the dynamics of the place worked," she said.
"It was very sexist, very sexist. People were doing crazy drugs at the time. I was oblivious. I just thought, 'Oh wow. He's got a lot of energy'," she added.
The two comedians took part in a Qiamp;A session during the Montclair Film Festival held in Montclair in New Jersey, where they discussed Louis-Dreyfus' career from "Saturday Night Live" to "Seinfeld" to her successful "Veep".
Despite "Saturday Night Live" not being the right fit for her, Louis-Dreyfus found a silver lining in working on the show.
"It was a pretty brutal time, but it was a very informative time for me," she said, as it taught her to value the "fun-meter" of her subsequent jobs.
"I learned I wasn't going to do any more of this show-business crap unless it was fun. I don't have to walk and crawl through this kind of nasty glass if it's not ultimately going to be fulfilling, and so that's how I sort of moved forward from that moment. I sort of applied that 'fun meter' to every job I've had since and that has been very helpful," she explained.