During her interview with Stern, the "Friends" star, 50, confirmed that she is enjoying being single after her split from husband Justin Theroux.
"Yeah, and I'm very busy. For now. I'm promoting ('The Morning Show'). I'm prepping for next season," she said.
Aniston has been married twice, first to Brad Pitt from 2000 to 2005 and then to Theroux from 2015 until their separation in 2017.
Stern jokingly asked her whether she would want him to set her up with a special someone.
"Not right now... But listen, I just don't like being set up. I don't like it. Hate it," she said.
The actress's gig on "The Morning Show", which will premiere on November 1 on Apple TV+, marks her first full-time television role since "Friends", which ended in 2004.
In the new drama, she plays Alex Levy, a TV anchor who goes it alone after her co-host, played by Steve Carell, is fired for alleged sexual misconduct -- while she contends with an ambitious journalist, played by Reese Witherspoon.