Teams will play four ODIs each in 11 days in Fort Lauderdale between September 13 and 23 with an aim to make their mark on the league table.
With teams two steps away from qualifying for the 2023 edition of the World Cup, there is a great deal at stake in this series.
Four of the 36 ODIs that USA, PNG and Namibia will play over the next two and a half years will take place in Fort Lauderdale with a maximum of eight points up for grabs for each team.
Tri-series 1 of the World Cup League 2 took place last month with a winless PNG looking to earn their first point of the competition in the US. Scotland sit above Oman on net-run-rate with both teams winning three games each.