Starting second, Rossi swept across the nose of Honda-powered pole qualifier Colton Herta to complete an outside pass as the pair entered the tight right-hand Turn 3 on the opening lap, and never looked back after taking the lead. Once in front, Rossi continued to build his advantage throughout the 55-lap event, heading the field by eight seconds just prior to the first round of pit stops; building that margin to 16 seconds by the second round, and eventually romping to a winning margin of more than 28 seconds in the caution-free event.
Rossi surrendered the lead only once, during the final round to pit stops on Lap 40, to fellow Honda driver Graham Rahal, who elected to run one additional lap prior to making his final stop.
For his part, Rahal spent the second half of the race in a multi-car fight over the third place. While Will Power ran a relatively uncontested second for the final 20 laps, Rahal battled championship leader Josef Newgarden and fellow Honda drivers Herta, James Hinchcliffe, Scott Dixon and Felix Rosenqvist for the final podium spot. With Herta on a different tire strategy throughout the race, the order shuffled several times in the closing laps before Newgarden held on to third by 1.5 seconds over Rahal.
Recovering from opening lap contact and a spin that dropped him to the rear of the field, defending series champion Dixon fought his way back to a fifth-place finish, followed by his Chip Ganassi Racing teammate, Rosenqvist. A slide in Turn 5 from Herta on Lap 53 cost both the rookie and Hinchcliffe, as Hinchcliffe finished finished seventh and Herta eighth.