Women represent a particularly vulnerable population, with higher rates of addiction following exposure to drugs, said researcher Erin Calipari, Assistant Professor at Vanderbilt University in the US.
"Women becoming addicted to drugs may be a fundamentally different process than men," she said. "It's important to understand this, because it's the first step in developing treatments that are actually effective," Calipari said.
The next step, she said, would be to figure out specifics of how hormonal shifts affect women's brains and, ultimately, develop medications that could help override those.
In this study, male and female rats were allowed to dose themselves with cocaine by pushing a lever, with a light set up to come on during dosing.
That's similar to the environmental cues, such as drug paraphernalia, present when humans are taking drugs.
When hormone levels were high, female rats made stronger associations with the light and were more likely to keep pushing the lever as much as it took to get any amount of cocaine.
Females were willing to "pay" more in the presence of these cues to get cocaine, the findings showed.
The results are transferable to humans through behavioural economic analysis, which uses a complicated mathematical equation with values for the most and least a subject will do to get a payoff, said the study.