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Key Points

A new international study shows that a higher weekly dose of semaglutide is both safe and effective for weight loss in obese adults. The 7.2 mg dose resulted in nearly 19% weight loss for those without diabetes and 13% for those with type 2 diabetes. Participants also experienced improvements in key health markers including blood pressure, cholesterol, and blood sugar levels. The research team noted that this higher dose could help more people achieve their health goals while reducing obesity-related complications worldwide.

Key Points: Higher Semaglutide Dose Safe and Boosts Weight Loss in Obesity Study

  • Higher 7.2 mg dose led to 19% weight loss in non-diabetic obese adults
  • Nearly half of participants lost 20% or more of body weight
  • Significant improvements in blood pressure, cholesterol and blood sugar levels
  • Higher dose was safe and well-tolerated with manageable side effects
2 min read

Higher doses of semaglutide safe, can aid in better weight loss for obese adults: Study

International study finds 7.2 mg semaglutide dose safe and significantly improves weight loss in obese adults, including those with type 2 diabetes.

"The higher dose could help more people reach their health goals and reduce the burden of obesity-related complications worldwide - Research Team"

New Delhi, Sep 15

A higher weekly dose of semaglutide (7.2 mg) is safe and can significantly improve weight loss in adults living with obesity, including those with type 2 diabetes (T2D), according to an international study, published on Monday.

The findings, based on results of two large-scale, international phase 3 clinical trials and published in The Lancet Diabetes & Endocrinology journal, suggest that a higher dose of semaglutide offers a promising new option for people who have not achieved sufficient weight loss with existing treatments.

“The currently approved dose of semaglutide is 2.4 mg, and the study showed 7.2 mg is safe and leads to additional weight reduction,” said the researchers, including those from Canada, the US, Denmark, Norway, and Portugal.

In adults without diabetes, a 7.2 mg dose of semaglutide led to an average weight loss of nearly 19 per cent, surpassing the 16 per cent loss seen with 2.4 mg and 4 per cent with placebo.

Nearly half of the participants on the higher dose lost 20 per cent or more of their body weight, with about one-third losing at least 25 per cent.

“Participants also experienced improvements in waist circumference, blood pressure, blood sugar, and cholesterol levels, all key factors in reducing obesity-related health risks,” the researchers said.

Similarly, in adults with obesity and T2D, the 7.2 mg dose resulted in an average 13 per cent weight loss compared to 10 per cent with 2.4 mg and 3.9 per cent with placebo, along with significant reductions in blood sugar levels and waist size.

Both trials reported that the higher dose of semaglutide was safe and generally well tolerated.

Gastrointestinal side effects like nausea and diarrhoea, and some sensory symptoms like tingling, were the most common. However, most side effects were manageable, resolved over time, and did not lead to participants dropping out of the trial. No increase in serious adverse events or severe hypoglycemia was observed with the higher dose.

“The higher dose could help more people reach their health goals and reduce the burden of obesity-related complications worldwide,” said the team, including those from the University of Porto, while also highlighting the need for further research to fully understand the long-term benefits and risks.

- IANS

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Reader Comments

R
Rahul R
Great research but I hope this becomes affordable for the common person. Medical treatments in India are already so expensive. Will government hospitals provide this treatment?
S
Sarah B
As someone who has struggled with weight management, these results are encouraging. The 19% weight loss figure is impressive, though the gastrointestinal side effects sound challenging. Hope long-term studies confirm the safety.
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Vikram M
While medical solutions are important, we shouldn't forget our traditional Indian approaches to health - yoga, balanced diet, and ayurveda. Modern medicine + traditional wisdom = best combination for health! 💪
A
Anjali F
My mother has type 2 diabetes and weight issues. This gives me hope! The improvement in blood sugar AND weight is exactly what many Indian families need. Hope it reaches patients soon.
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Michael C
Important to note that nearly half participants lost 20%+ weight - that's significant. But we need to see how sustainable this is long-term. Weight management is a lifelong journey, not just about medication.
K
Karthik V
Good research but I'm concerned about the tingling sensation side effect mentioned. Hope they study this more thoroughly before making it widely available. Safety should be the top priority.

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