Afraid of needles? A puff of air could deliver your next vaccine
According to the team from the University of Texas at Dallas, the new injector can have a wide number of applications, from veterinary medicine to agriculture, or someday even human vaccinations or treatments.
New York, March 27: For people frightened of needles, US researchers have developed a system driven by compressed gas that can deliver vaccines and biologics into the human body in a relatively painless way.
They presented their results at the ongoing spring meeting of the American Chemical Society (ACS).
During Covid pandemic, principal investigator Jeremiah Gassensmith bought inexpensive pieces of a compressed gas-powered jet injection system to mess around.
After returning to campus, he handed the pieces over to Yalini Wijesundara, a graduate student in the lab, who had previously researched other jet injectors dating back to the 1960s that use compressed gas to inject a narrow stream of fluid.
Wijesundara figured out that they could deliver cargo encased in metal-organic frameworks, or MOFs.
These frameworks are porous, crystalline structures that act like molecular "cages" to encapsulate a wide variety of materials, including nucleic acids and proteins.
They created "MOF-Jet" to deliver powders to cells by, quite literally, shooting them in with air.
The team placed the cargo inside a MOF known as zeolitic-imidazolate framework eight (ZIF-8). The cargo, they decided, would be in the form of a powder rather than liquid, eliminating the need to store the vaccine at cold temperatures.
To test their system, they delivered a ZIF-8 encased gene to onion cells as well as a ZIF-8 encased protein to mice.
Further the researchers said because the MOF-Jet can disperse material over a wide area, it could also distribute a cancer therapeutic into a melanoma more evenly than with a needle, which is the current delivery method.
And simply by controlling the carrier gas, they could deliver chemotherapeutics with a fast- or slow-release timeframe, depending on a patient's needs.
Afraid of needles? A puff of air could deliver your next vaccineIANS 27 March 2023 Post Your Comments
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