health-news

Rare gene variants that double Alzheimer's disease risk identified

Washington, Dec. 12 : A team of researchers have identified rare variations in a gene that doubles a person's risk of developing Alzheimer's disease later in life.


The newly identified variations, found in a gene never before linked to Alzheimer's, occur rarely in the population, making them hard for researchers to identify. But they're important because individuals who carry these variants are at substantially increased risk of the disease.

Finding mutations linked to Alzheimer's disease means it may be possible to identify more people at risk years before they develop any symptoms. These patients could be monitored carefully for early signs of Alzheimer's and possibly even get treatments to slow the progression of the disease.

As in many genetic studies of Alzheimer's, Carlos Cruchaga from Washington University School of Medicine in St. Louis and his co-investigators analyzed DNA from people in families in which multiple members were affected by the disease.

They sequenced all the protein-coding genes from several individuals in each of the 14 families, using a technique called whole exome sequencing. Some of these family members had an Alzheimer's diagnosis but others did not.

The investigators compared DNA from affected individuals in a family to those in the same family who didn't have the disorder. Eventually, they identified two families that carried the same variation in the phospholipase-D 3 gene (PLD3). The variation was present in affected family members but not in the elderly family members who did not have Alzheimer's disease.

Additional experiments conducted in the laboratory showed that when the PLD3 gene is active, levels of amyloid-beta decline. This substance aggregates in the brains of Alzheimer's patients to form plaques. When the researchers decreased expression of PLD3, levels of amyloid-beta increased.

The researchers said that the experiment strongly suggested that PLD3 is influencing Alzheimer's disease risk by regulating the activity of the gene that makes amyloid.

The study is published in the journal Nature.

--ANI (Posted on 13-12-2013)

health-news headlines

Can too much exercise be a bad thing?

New method to treat cocaine addiction effectively

Aspirin can lower colorectal cancer risks for people with specific gene

Aspirin may cut down colon cancer risks too

Prenatal smoking linked to enhanced aggressive behavior in children

Novel compound could halt cocaine addiction and relapse behaviors

Red meat could up heart disease risk

Vitamin D supplements have little effect on risk of falls among older people: Lancet

Marijuana use could up heart complications in young, middle-aged adults

Acupuncture improves activation of functional brain areas in stroke sufferers

Binge drinking could make you overeat

Blood test that can predict who will suffer from arthritis to be available in 5 yrs

Quick Links: Goa | Munnar | Pondicherry | Free Yearly Horoscope '2014

Comments

Your e-mail:


Your Full Name:


Type verification image:
verification image, type it in the box

Message:

Back to Top