health-news

Two-drug combo could help treat cancer

Washington, Dec. 12 : One drug attacks tumor cells directly, the other treats the immune system by taking the brakes off T cell response, and together, they put half of the patients with relapsed follicular lymphoma into complete remission.


Senior author Sattva Neelapu, M.D., Ph.D., associate professor of Lymphoma/Myeloma at MD Anderson, said that most drugs target only the tumor, this combination is complementary, treating both the lymphoma cells directly and the T cells in a manner that activates them against cancer cells.

He said that the combination of the established antibody drug rituximab with the experimental drug pidilizumab so far also has a remarkably mild side effect profile.

Of 29 study participants at a median follow-up of 15.4 months, 19 (66 percent) had either a complete or partial response, with 15 (52 percent) having a complete response.

There were no grade 3 or 4 adverse events, with all effects at the less serious grade 1 and 2 levels. Patients had no indicators of autoimmunity, which can be an issue in the class of drugs that blocks immune system checkpoints and activate T cells. Such mild effects are particularly important for follicular lymphoma patients, who are diagnosed with the disease at a median age of 60.

Neelapu said that Rituximab treatment alone usually achieves a 40 percent overall response rate and about 11 percent complete responses, asserting that the side effect profile of the combination is about the same as rituximab alone.

He added pidilizumab greatly improves responses so far at little cost in additional side effects.

The study has been published in the journal The Lancet Oncology.

--ANI (Posted on 13-12-2013)

health-news headlines

Ear implant may help regrow auditory nerves: Study

Colon cancer linked to dietary fats

Now, smart pill bottle that help you take your meds on time

Ginseng can help treat and prevent influenza and respiratory virus

Now, 3D-printed plaster cast to heal wound faster

How bariatric surgery can help control diabetes

McDonaldisation of gym culture spreading fast: Study

New drug to treat depression?

Now, the ICU comes home - at a fraction of the cost (Health Feature)

Malnutrition not priority for most parties: CRY

Testosterone levels in womb may impact your health

Bone marrow can cure blood disorders

Quick Links: Goa | Munnar | Pondicherry | Free Yearly Horoscope '2014

Comments

Your e-mail:


Your Full Name:


Type verification image:
verification image, type it in the box

Message:

Back to Top