special-features

Slowing aging process could help treat Alzheimer's, Parkinson's and Huntington's

Washington, Dec 04 : Researchers have found that a new and unique compound, named NT219, selectively inhibits the process of aging in order to protect the brain from neurodegenerative diseases, without affecting lifespan.


The successful joint collaboration between researchers at the Hebrew university of Jerusalem and the startup company TyrNovo is an important step towards the development of future drugs for the treatment of various neurodegenerative maladies.

Human neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington's diseases share two key features: they stem from toxic protein aggregation and emerge late in life.

The common temporal emergence pattern exhibited by these maladies proposes that the aging process negatively regulates protective mechanisms that prevent their manifestation early in life, exposing the elderly to disease.

Dr. Hadas Reuveni, the CEO of TyrNovo, a startup company formed for the clinical development of NT219, and Prof. Alexander Levitzki from the Department of Biological Chemistry at the Hebrew University, with their research teams, discovered a new set of compounds that inhibit the activity of the IGF1 signaling cascade in a unique and efficient mechanism, primarily for cancer treatment, and defined NT219 as the leading compound for further development.

Now, the researchers have demonstrated that NT219 efficiently inhibits IGF1 signalling, in both worms and human cells. The inhibition of this signalling pathway by NT219 protected worms from toxic protein aggregation that in humans is associated with the development of Alzheimer's or Huntington's disease.

The findings strengthen the notion that the inhibition of the IGF1 signalling pathway has a therapeutic potential as a treatment for neurodegenerative disorders. They also point at NT219 as the first compound that provides protection from neurodegeneration-associated toxic protein aggregation through a selective manipulation of aging.

The study was published in the journal Aging Cell.

--ANI (Posted on 04-12-2013)

special-features headlines

Fear tactics used by teachers result in lower scores

Now, generate electricity by just flushing your toilet

'Increasing alcohol price can slow down serious violence'

Most men last only 2 minutes in bed: Expert

Kids who bite food may become rowdy: Study

Vision moves to upper half first: Study

Too much admiration for partner bad for romance

Why married women cheat revealed

Why massages ease muscle soreness post workouts

How to keep spring's glow on face

Soon, powdered alcohol to give you a high

Learn Japanese from this bird, for free!

Quick Links: Goa | Munnar | Pondicherry | Free Yearly Horoscope '2014

Comments

Your e-mail:


Your Full Name:


Type verification image:
verification image, type it in the box

Message:

Back to Top