health-news

Targeted treatment chemo combo prolongs lives of ovarian cancer sufferers

Washington, Oct 12 : A new study has claimed that conventional chemotherapy could further prolong lifespan in some women with ovarian cancer when used in tandem with a new type of targeted treatment.


The research provides important evidence that PARP inhibitor drugs and chemotherapy can both be effective in the same patients, helping women live longer than they would if treated with chemotherapy alone.

The study, in women with mutations to BRCA genes - which increase the risk that ovarian cancer will relapse after treatment, as well as being linked to breast and other cancers - showed that ovarian cancers that have become resistant to PARP inhibitors often remain sensitive to conventional chemotherapy.

The study was led by researchers at The Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust, and looked at follow-up data from patients who had previously taken part in clinical trials sponsored by pharmaceutical company AstraZeneca.

The research was supported by grants from the Experimental Cancer Medicine Centre and a range of institutions including Cancer Research UK, the National Institute for Health Research and the Wellcome Trust.

The researchers monitored 89 patients with BRCA-mutated ovarian cancer at The Royal Marsden and other hospitals in the UK, Australia, Belgium, Israel and North America, all of whom received chemotherapy following the development of resistance to a PARP inhibitor called olaparib.

Almost half (49 per cent) of olaparib-resistant patients showed a significant decrease in the size of their tumours when subsequently treated with platinum-based chemotherapy, a frequently-used treatment in ovarian cancer.

The results show that a significant proportion of women with ovarian cancer could live longer if they received both treatments.

The study is published in the journal Clinical Cancer Research.

--ANI (Posted on 12-10-2013)

health-news headlines

Timeless beauty tips to follow

Cellulite facts worth knowing

Want to de-stress? Sex can help you

People are more concerned about their health at start of the week than weekends

Brain's anti-distraction system found

Chronic inflammation associated with aggressive prostate cancer

Easter chocolate can be good for health

'Smart' device that engineers cells to kill cancer

Lost stem cells are replaced by non-stem cells: Study

Brown fat breakthrough may be 'holy grail' of weight loss

Tuberculosis drug could also help treat other diseases

New method to fight Malaria drug resistance discovered

Quick Links: Goa | Munnar | Pondicherry | Free Yearly Horoscope '2014

Comments

Your e-mail:


Your Full Name:


Type verification image:
verification image, type it in the box

Message:

Back to Top