health-news

Possible culprit behind congenital heart defects discovered

Washington, Oct. 6 : Researchers have shown that mitochondria has the ability to orchestrate events that determine a cell's future, at least in the embryonic mouse heart.


Gerald W. Dorn II, MD, the Philip and Sima K. Needleman Professor of Medicine at Washington University said that this study is surprising because biologists always assumed that organ development was orchestrated from the nucleus of a cell, and that the mitochondria simply followed along and did what they were told.

He said that they've shown that mitochondria can direct what type of tissue a cell will become during embryonic development.

Luca Scorrano, MD, PhD, professor of biochemistry at the University of Padua-Dulbecco Telethon Institute in Italy said that using a tissue culture technique he calls "hearts in the tube," they were able to unravel a novel way used by the ancient invader to take control of cell fate.

The researchers were careful to note that the underdeveloped hearts were not simply the result of a lack of fuel from dysfunctional mitochondria. Scorrano's team showed that these fragmented mitochondria, small and separated because they could not fuse together, interrupt well-known signaling pathways that govern how the nucleus expresses genes.

Several of these signaling pathways already are implicated in congenital heart defects, such as those that result in holes in the wall separating the left and right ventricles, called ventricular septal defects.

The study has been published in Science Express.

--ANI (Posted on 06-10-2013)

health-news headlines

How memories stick together

Leeches can fix torn ear!

Oral drug holds promise to eradicate deadly measles

Period pain affects work of girls: Research

Yoga may be the answer to infertility

Weight loss surgery linked to appetite, taste change

'Vitamin supplements no substitute for natural foods'

How food texture affects our calorie intake

Cheap 'magic' polypill helps fight heart diseases

Extroverts make for happier humans across cultures

Low-calorie restaurant menus may be making us unhealthier

Why rice is good for your health

Quick Links: Goa | Munnar | Pondicherry | Free Yearly Horoscope '2014

Comments

Your e-mail:


Your Full Name:


Type verification image:
verification image, type it in the box

Message:

Back to Top