technology-news

Scientists uncover keys to antibiotic resistance in superbug

Washington, Oct 05 : A new study has revealed the mechanistic basis for how the methicillin-resistant Staphylococcus aureus (MRSA) bacterium became such a difficult pathogen over the previous 50 years, in which time it spread rapidly across the world.


The study by researchers at university of Notre Dame and their collaborators in Spain showed how MRSA regulates the critical crosslinking of its cell wall in the face of beta-lactam antibiotics.

Modern strains of MRSA have become broadly resistant to antibiotics, including beta-lactam antibiotics, such as penicillins.

In their report, the researchers disclose the discovery of an allosteric domain in the X-ray structure of the penicillin binding protein 2a of MRSA, the enzyme that carries out the crosslinking reaction.

The researchers documented that an allosteric trigger by a fragment of the cell wall at a distance of 60 ...ngstroms (6 nanometers) activates a set of conformational changes that culminates in the opening of the active site from a closed conformation, enabling catalysis for the physiological role of the enzyme.

They also documented that the new beta-lactam antibiotic ceftaroline, recently approved by the Food and Drug Administration, is able to bind to the allosteric domain and trigger the same allosteric opening of the active site. This subversion of the allosteric control allows another molecule of ceftaroline to access the active site, which inhibits the function of the enzyme, leading to cell death by MRSA.

The study is published in the Proceedings of the National Academy of Sciences.

--ANI (Posted on 05-10-2013)

technology-news headlines

Ancient tundra landscape discovered under Greenland Ice Sheet

NASA's Kepler Space Telescope finds Earth's twin

Concrete that never gets a crack!

Tiny robots to help you perform daily chores

Fossil of 325-million-year-old shark-like specie sheds light on evolution of jaws

Soon, wireless power zones to charge your phone

Soon, cheap computers and 'throwaway' cell phones

Scientists identify target for treating dengue

Waste sulphur to produce cheap infra-red devices

When meteors delivered vitamin B3 at your doorstep!

Believe it! These females have penises

How dust affects light reaching us from stars

Quick Links: Goa | Munnar | Pondicherry | Free Yearly Horoscope '2014

Comments

Your e-mail:


Your Full Name:


Type verification image:
verification image, type it in the box

Message:

Back to Top