technology-news

Cancer drug has potential to treat diabetes

Washington, Sept 16 : A new research has found that a cancer drug has the potential to treat diabetes.


A pair of studies by researchers at the Stanford University School of Medicine has identified a molecular pathway - a series of interaction among proteins - involved in the development of diabetes. Furthermore, they have found that a drug already approved for use in humans can regulate the pathway.

The studies, done in mice, identify a previously unexpected link between a low-oxygen condition called hypoxia and the ability of cells in the liver to respond to insulin.

The drug, aflibercept (marketed as Eylea or Zaltrap), is used to treat metastatic colorectal cancer and a form of macular degeneration.

Aflibercept is a member of a family of proteins that inhibit the vascular endothelial growth factor, or VEGF, pathway.

It works by blocking the growth of the blood vessels into tumors and starving them of oxygen.

The lab of Calvin Kuo, MD, PhD, professor of medicine, identified a series of protein interactions that link VEGF inhibitors and blood glucose levels.

"We were surprised to find that this drug currently used in patients for cancer treatment had beneficial effects on diabetes in laboratory mice and could, potentially, in humans," Kuo, senior author of one of the Nature Medicine papers, said.

Amato Giaccia, PhD, the Jack, Lulu and Sam Willson Professor of Cancer Biology, is senior author of the other paper.

"Proteins involved in this pathway could also be targeted for the development of new diabetes therapies," Giaccia, who also is a professor and director of radiation oncology, said.

His laboratory has identified a protein called PhD3 that could be a particularly attractive target.

The findings are published online in Nature Medicine.

--ANI (Posted on 16-09-2013)

technology-news headlines

This space selfie not to be missed!

Mysterious 'duck' sound came from rare antarctic whales

Y chromosome was born 180 million years ago: Study

Here are scent-filled bubbles for your kids

In a first, scientists regrow auditory nerves in lab

New groundbreaking technique may help cure diseases by 'editing' DNA

Ancient Antarctica was as warm as today's California coast

Domesticated chili pepper originated in Central-east Mexico

Neanderthals carried more copies of potentially detrimental mutations

'Upside-down planet' reveals new method for studying binary star systems

Learn why homo sapiens survived when others could not

New material prevents plastic from ageing

Quick Links: Goa | Munnar | Pondicherry | Free Yearly Horoscope '2014

Comments

Your e-mail:


Your Full Name:


Type verification image:
verification image, type it in the box

Message:

Back to Top