The pharmacological and toxicological mechanisms of ethanol are considered to be related to the effects of ceramide.
As an important signal transduction molecule, ceramide participates in a variety of cellular transduction pathways and can modulate cell cycle, cellular differentiation, proliferation, and apoptosis.
A recent study verified that ceramide is involved in alcohol-induced neural proliferation in the hippocampal dentate gyrus of pups after prenatal ethanol exposure, and the mechanism may be associated with increased ex-pression of protein kinase C activating the ceramide/ceramide-1-phosphate pathway.
The study is published in the Neural Regeneration Research.
--ANI (Posted on 16-09-2013)