health-news

Key antioxidant that can protect against Huntington's disease discovered

Washington, Aug 26 : Researchers have identified that glutathione peroxidase activity - a key antioxidant in cells - protects against symptoms of Huntington's disease in model organisms.


Huntington's disease is a fatal neurodegenerative disorder which currently has no cure.

The team of University of Leicester researchers carried out research for more than six years to identify new potential drug targets for the disease.

They used model systems, such as baker's yeast, fruit flies, and cultured mammalian cells to help uncover potential mechanisms underlying disease at the cellular level.

They initially screened a genome-wide collection of yeast genes and found several candidates which protected against Huntington's related symptoms in yeast. They then validated their findings in fruit flies and mammalian cells, and found that glutathione peroxidase activity is robustly protective in these models of Huntington's disease.

The team now aims to further validate the observations regarding glutathione peroxidase activity, in order to understand whether this could have therapeutic relevance for Huntington's.

In addition, they have identified many additional genes that are protective and aim to further explore these to see if there are any additional therapeutic possibilities suggested by their research.

The study was published in journal Nature Genetics.

--ANI (Posted on 27-08-2013)

health-news headlines

Can too much exercise be a bad thing?

New method to treat cocaine addiction effectively

Aspirin can lower colorectal cancer risks for people with specific gene

Aspirin may cut down colon cancer risks too

Prenatal smoking linked to enhanced aggressive behavior in children

Novel compound could halt cocaine addiction and relapse behaviors

Red meat could up heart disease risk

Vitamin D supplements have little effect on risk of falls among older people: Lancet

Marijuana use could up heart complications in young, middle-aged adults

Acupuncture improves activation of functional brain areas in stroke sufferers

Binge drinking could make you overeat

Blood test that can predict who will suffer from arthritis to be available in 5 yrs

Quick Links: Goa | Munnar | Pondicherry | Free Yearly Horoscope '2014

Comments

Your e-mail:


Your Full Name:


Type verification image:
verification image, type it in the box

Message:

Back to Top