health-news

Effects of exercise on ulcerative colitis explored

Washington, July 3 : A new study indicates that aerobic exercise can be a boon or a bane for patients of inflammatory bowel diseases such as ulcerative colitis, depending on how it is undertaken.


The researchers found that, in contrast to their sedentary peers, mice allowed to run freely on an exercise wheel for six weeks had fewer symptoms of colitis after exposure to a chemical agent that induces colitis symptoms in mice.

However, mice forced to run at a moderate pace on a treadmill a few times per week for six weeks had more colitis symptoms and higher mortality after exposure to the agent than sedentary mice, the researchers found.

These seemingly contradictory findings add to a growing body of research into the role of exercise and stress in reducing or increasing the severity of a host of inflammatory states, including those associated with Alzheimer's disease and infection with the influenza virus.

"We are building a strong case to investigate how exercise affects gut immune function in humans and why exercise may beneficially affect disease activity in ulcerative colitis patients, as a few preliminary studies have indicated," said University of Illinois graduate student Marc Cook, who led the research with U. of I. kinesiology and community health professor Jeffrey Woods. "Our exciting new data give us some potential causes of these benefits that need to be tested in people, which is our ultimate goal."

The scientists also found that voluntary wheel running significantly reduced the expression of some pro-inflammatory genes in the colon in the mouse model of colitis, while forced treadmill running significantly increased expression of many of those same genes. Forced running on a treadmill by itself, but not voluntary wheel running, also increased expression of an antibacterial signaling protein, suggesting that forced exercise disrupted the microbial environment of the gut.

"There is evidence that prolonged, intense exercise can cause gastrointestinal disruption in competitive athletes. However, very little is known about regularly performed moderately intense exercise, especially in those with inflammatory bowel diseases," Woods said. "From a public health perspective, this would be important information to gather."

In humans, inflammatory bowel diseases "cause chronic morbidity that significantly reduces physical functioning and quality of life in afflicted patients," the authors wrote.

Although more studies must be conducted to clarify the interplay of exercise and stress in maintaining or undermining the health of the gut, the research "supports a role for exercise in the adjunct treatment of ulcerative colitis in humans," the authors wrote.

The study has been published in the journal Brain, Behavior, and Immunity.

--ANI (Posted on 03-07-2013)

health-news headlines

Colon cancer linked to dietary fats

Now, smart pill bottle that help you take your meds on time

Ginseng can help treat and prevent influenza and respiratory virus

Now, 3D-printed plaster cast to heal wound faster

How bariatric surgery can help control diabetes

McDonaldisation of gym culture spreading fast: Study

New drug to treat depression?

Now, the ICU comes home - at a fraction of the cost (Health Feature)

Malnutrition not priority for most parties: CRY

Testosterone levels in womb may impact your health

Bone marrow can cure blood disorders

Heart's development doesn't stop with birth

Quick Links: Goa | Munnar | Pondicherry | Free Yearly Horoscope '2014

Comments

Your e-mail:


Your Full Name:


Type verification image:
verification image, type it in the box

Message:

Back to Top