health-news

Combined medication helps smokers kick the butt more than single drug therapy

Washington, Jan. 12 : A team of researchers has found that among cigarette smokers, combining the smoking cessation medications varenicline and bupropion, compared with varenicline alone, resulted in higher smoking abstinence rates.


"We were interested in seeing if combining different medications together can improve the ability of patients to quit over and above single drug therapy," lead author Jon Ebbert, M.D., Mayo Clinic Nicotine Dependence Center, said. "What we found was an increase in quit rates, and the increase in quit rates was particularly strong in heavier and more dependent smokers."

The study authors looked at the efficacy of combining the medications varenicline and bupropion SR (sustained-release) for smoking cessation, compared with varenicline alone (monotherapy).

In addition, the research team analyzed data based on participants' smoking rate and level of nicotine dependence.

Cigarette smokers were randomized to 12 weeks of varenicline and bupropion SR or varenicline and placebo with follow-up through 52 weeks. The primary outcome was smoking abstinence rates at week 12, defined as prolonged abstinence (no smoking from two weeks after the target quit date) and seven-day point-prevalence abstinence (no smoking past seven days). Outcomes were confirmed with an exhaled breath test for carbon monoxide.

Combination therapy was associated with significantly higher prolonged smoking abstinence rates at 12 (53 percent vs. 43.2 percent) and 26 weeks (36.6 percent vs. 27.6 percent) compared with varenicline alone.

No significant differences were observed between the two groups at any time point for seven-day point-prevalence smoking abstinence. Anxiety was reported more commonly with combination therapy than with varenicline monotherapy, as were depressive symptoms.

The study was published in journal JAMA.

--ANI (Posted on 12-01-2014)

health-news headlines

'Unproven treatment of spinal injuries can cause paralysis'

Can too much exercise be a bad thing?

New method to treat cocaine addiction effectively

Aspirin can lower colorectal cancer risks for people with specific gene

Aspirin may cut down colon cancer risks too

Prenatal smoking linked to enhanced aggressive behavior in children

Novel compound could halt cocaine addiction and relapse behaviors

Red meat could up heart disease risk

Vitamin D supplements have little effect on risk of falls among older people: Lancet

Marijuana use could up heart complications in young, middle-aged adults

Acupuncture improves activation of functional brain areas in stroke sufferers

Binge drinking could make you overeat

Quick Links: Goa | Munnar | Pondicherry | Free Yearly Horoscope '2014

Comments

Your e-mail:


Your Full Name:


Type verification image:
verification image, type it in the box

Message:

Back to Top