New worm research could help humans live for 500 years

Washington, Dec. 13 : If what works for worms can be applied to humans, then living to the ripe old age of 500 might be a possibility for us too, a new study has shown.

Experts tweaked two genetic pathways in the lab worm Caenorhabditis elegans and increased its lifespan five-fold, reported.

US lead scientist Dr Pankaj Kapahi, from the Buck Institute of Age Research, said that the two mutations set off a positive feedback loop in specific tissues that amplified lifespan, asserting that the worms lived to the human equivalent of 400-500 years.

According to Kapahi, while living for hundreds of years would be difficult, the study has raised the prospect of anti-ageing treatments based on genetic interactions.
The new study involves blocking key molecules affecting the insulin action and a nutrient signalling pathway called Target of Rapamycin (TOR).

Single mutations in the TOR pathway were known to up the lifespan of C. elegans by 30 per cent, while insulin-signalling mutations could double the amount of time they lived; adding the two together was expected to extend longevity by 130 per cent - but it turned out to be much higher.

The new research has been published in the journal Cell Reports.

--ANI (Posted on 15-12-2013)

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