Scientists explain how fever originated
Scientists have discovered the reason behind one of the most common medical signs characterized by rise in body temperature, fever.
Fever is a response to inflammation, and is triggered by an onset of the signaling substance prostaglandin. Senior lecturer David Engblom from Linkoping University, Sweden, had had a breakthrough eleven years ago when he uncovered the mechanism behind the formation of prostaglandin E2 during fever.
These signaling molecules could not pass the blood-brain barrier, the purpose of which is to protect the brain from hazardous substances. Engblom showed that instead, they could be synthesised from two enzymes in the blood vessels on the inside of the brain, before moving to the hypothalamus, where the body's thermostat is located.
The study was based on tests with mice that lacked the enzymes COX-2 and mPGES-1 in the brain's blood vessels. When they were infected with bacterial toxins the fever did not appear, while other signs of inflammation were not affected.
David Engblom explained that this showed that those prostaglandins which cause fever were formed in the blood-brain barrier and nowhere else.
The study is due to be published in the Journal of Neuroscience.
(Posted on 27-08-2014)
Information on States of India:
Andaman Nicobar | Andhra Pradesh | Assam | Bihar | Chandigarh | Chhattisgarh | Dadar Nagar Haveli | Daman Diu | Delhi | Goa | Gujarat | Haryana | Himachal Pradesh | Jammu Kashmir | Jharkhand | Karnataka | Kerala | Lakshadweep | Madhya Pradesh | Maharashtra | Manipur | Meghalaya | Mizoram | Nagaland | Orissa | Pondicherry | Punjab | Rajasthan | Sikkim | Tamil Nadu | Tripura | Uttar Pradesh | Uttaranchal | West Bengal
INDIA REGIONAL MAPS:
Andhra Pradesh Travel Map | Bihar Travel Map | Goa Travel Map | Gujarat Travel Map | Haryana Travel Map | Himachal Pradesh Map | Karnataka Travel Map | Kerala Travel Map | Maharashtra Travel Map | Punjab Travel Map | Rajasthan Travel Map | Sikkim Travel Map | Tamil Nadu Travel Map | Uttar Pradesh Travel Map | West Bengal Travel Map |
MORE MAPS OF INDIA:
INDIA CITY MAPS:
KERALA TRAVEL MAPS: