Cradle of obesity lies in the brain
A new study has demonstrated that the curing of weight gain, obesity, and diabetes could be as simple as keeping a nuclear receptor from being activated in a small part of the brain.
The study by Yale School of Medicine researchers showed that when the researchers blocked the effects of the nuclear receptor PPARgamma in a small number of brain cells in mice, the animals ate less and became resistant to a high-fat diet.
Lead author Sabrina Diano, professor in the Department of Obstetrics, Gynecology and Reproductive Sciences at Yale School of Medicine asserted that these animals ate fat and sugar, and did not gain weight, while their control littermates gained weight on the same diet.
Diano said that when they blocked PPARgamma in these hypothalamic cells, they found an increased level of free radical formation in POMC neurons, and they were more active.
Diano further said that their study suggested that the increased weight gain in diabetic patients treated with TZD could be due to the effect of this drug in the brain, therefore, targeting peripheral PPARgamma to treat type 2 diabetes should be done by developing TZD compounds that could not break in the brain.
The study is published in the issue of The Journal of Clinical Investigation (JCI).
(Posted on 03-08-2014)
Information on States of India:
Andaman Nicobar | Andhra Pradesh | Arunachal Pradesh | Assam | Bihar | Chandigarh | Chhattisgarh | Dadar Nagar Haveli | Daman Diu | Delhi | Goa | Gujarat | Haryana | Himachal Pradesh | Jammu Kashmir | Jharkhand | Karnataka | Kerala | Lakshadweep | Madhya Pradesh | Maharashtra | Manipur | Meghalaya | Mizoram | Nagaland | Orissa | Pondicherry | Punjab | Rajasthan | Sikkim | Tamil Nadu | Tripura | Uttar Pradesh | Uttaranchal | West Bengal
INDIA REGIONAL MAPS:
Andhra Pradesh Travel Map | Bihar Travel Map | Goa Travel Map | Gujarat Travel Map | Haryana Travel Map | Himachal Pradesh Map | Karnataka Travel Map | Kerala Travel Map | Maharashtra Travel Map | Punjab Travel Map | Rajasthan Travel Map | Sikkim Travel Map | Tamil Nadu Travel Map | Uttar Pradesh Travel Map | West Bengal Travel Map |
KERALA TRAVEL MAPS:
TRAVEL MAPS OF INDIA:
INDIA CITY MAPS: