New York, Feb 25 IANS | 6 months ago

What if scientists can decipher what happens to the virus before it gets inside cells? It can surely help them devise new methods to prevent infection altogether.


Researchers at New Jersey-based Princeton University have achieved an unprecedented 3D look at a virus-like particle as it tries to break into and infect a cell.

The technique could help scientists learn more about how to deliver drugs via nanoparticles - which are about the same size as viruses - as well as how to prevent viral infection from occurring.

"The challenge in imaging these events is that viruses and nanoparticles are small and fast, while cells are relatively large and immobile. That has made it very hard to capture these interactions," explained Kevin Welsher, a post-doctoral researcher in Princeton University's department of chemistry.

The researchers solved the problem by using two cameras - one that locked onto the virus-like nanoparticle and followed it faithfully and another filmed the cell and surrounding environment.

The new video reveals a virus-like particle zipping around in a rapid, erratic manner until it encounters a cell, bounces and skids along the surface, and slips into the cell's interior.

"What Welsher has done is really different. He can capture a three-dimensional view of a virus-sized particle attacking a living cell. This gives us a completely new level of understanding," said Haw Yang, associate professor of chemistry and Welsher's adviser.

The technology has potential benefits for both drug discovery and basic scientific discovery.

"This would impact the study of how nanoparticles can deliver medicines to cells, potentially leading to some new lines of defense in antiviral therapies," Welsher said in the research published in Nature Nanotechnology.

(Posted on 25-02-2014)


Information on States of India:

Andaman Nicobar | Andhra Pradesh | Assam | Bihar | Chandigarh | Chhattisgarh | Dadar Nagar Haveli | Daman Diu | Delhi | Goa | Gujarat | Haryana | Himachal Pradesh | Jammu Kashmir | Jharkhand | Karnataka | Kerala | Lakshadweep | Madhya Pradesh | Maharashtra | Manipur | Meghalaya | Mizoram | Nagaland | Orissa | Pondicherry | Punjab | Rajasthan | Sikkim | Tamil Nadu | Tripura | Uttar Pradesh | Uttaranchal | West Bengal

INDIA REGIONAL MAPS:

Andhra Pradesh Travel Map | Bihar Travel Map | Goa Travel Map | Gujarat Travel Map | Haryana Travel Map | Himachal Pradesh Map | Karnataka Travel Map | Kerala Travel Map | Maharashtra Travel Map | Punjab Travel Map | Rajasthan Travel Map | Sikkim Travel Map | Tamil Nadu Travel Map | Uttar Pradesh Travel Map | West Bengal Travel Map |

MORE MAPS OF INDIA:

Airports of India | Districts of India | India Pilgrim Centers | Tourism Map of India | National Highways in India | India Railway Routes |

INDIA CITY MAPS:

Ahmadabad | Bangalore | Chennai | Coimbatore | Delhi | Hyderabad/Secunderabad | Kochi | Kolkata | Mumbai | Pondicherry | Pune | Surat |

KERALA TRAVEL MAPS:

Alappuzha | Ernakulam | Idukki | Kannur | Kasaragod | Kollam | Kottayam | Kozhikode | Malappuram | Palakkad | Pathanamthitta | Thiruvananthapuram | Thrissur | Wayanad |